Pomin Lab: BioMolecular NMR and Glycobiology
The University of Mississippi

Publications

Peer-reviewed articles

  1. Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and heparin cofactor II-dependent anticoagulant activity. Pomin VH, Pereira MS, Valente AP, Tollefsen DM, Pavão MS, Mourão PA. Glycobiology 2005, 15:369-81;
  2. Mild acid hydrolysis of sulfated fucans: a selective 2-desulfation reaction and an alternative approach for preparing tailored sulfated oligosaccharides. Pomin VH, Valente AP, Pereira MS, Mourão PA. Glycobiology 2005, 15:1376-85;
  3. The Hemolymph of the ascidian Styela plicata (Chordata-Tunicata) contains heparin inside basophil-like cells and a unique sulfated galactoglucan in the plasma. de Barros CM, Andrade LR, Allodi S, Viskov C, Mourier PA, Cavalcante MC, Straus AH, Takahashi HK, Pomin VH, Carvalho VF, Martins MA, Pavão MS. J Biol Chem 2007, 282:1615-26;
  4. The renal clearance of dextran sulfate decreases in puromycin aminonucleoside-induced glomerulosclerosis: a puzzle observation. Santos AM, Pomin VH, Stelling MP, Guimarães MA, Cardoso LR, Mourão PA. Clin Chim Acta 2007, 383:116-25;
  5. A preponderantly 4-sulfated, 3-linked galactan from the green alga Codium isthmocladum. Farias EH, Pomin VH, Valente AP, Nader HB, Rocha HA, Mourão PA. Glycobiology 2008, 18:250-9;
  6. Structure, biology, evolution, and medical importance of sulfated fucans and galactans. Pomin VH, & Mourão PA. Glycobiology 2008, 18:1016-27;
  7. Review: an overview about the structure-function relationship of marine sulfated homopolysaccharides with regular chemical structures. Pomin VH. Biopolymers 2009, 91:601-9;
  8. A unique 2-sulfated {beta}-galactan from the egg jelly of the sea urchin Glyptocidaris crenularis: conformation flexibility versus induction of the sperm acrosome reaction. Castro MO, Pomin VH, Santos LL, Vilela-Silva AC, Hirohashi N, Pol-Fachin L, Verli H, Mourão PA. J Biol Chem 2009, 284:18790-800;
  9. Structural and functional insights into sulfated galactans: a systematic review. Pomin VH. Glycoconj J 2010, 27:1-12;
  10. Unique extracellular matrix heparan sulfate from the bivalve Nodipecten nodosus (Linnaeus, 1758) safely inhibits arterial thrombosis after photochemically induced endothelial lesion. Gomes AM, Kozlowski EO, Pomin VH, de Barros CM, Zaganeli JL, Pavão MS. J Biol Chem 2010, 285:7312-23;
  11. Effects of oversulfated and fucosylated chondroitin sulfates on coagulation. Challenges for the study of anticoagulant polysaccharides. Fonseca RJ, Oliveira SN, Pomin VH, Mecawi AS, Araujo IG, Mourão PA. Thromb Haemost 2010, 103:994-1004;
  12. Characterization of glycosaminoglycans by 15N-NMR spectroscopy and in vivo isotopic labeling. Pomin VH, Sharp JS, Li X, Wang L, Prestegard JH. Anal Chem 2010, 82:4078-88;
  13. LC-MSn Sequencing of Isomeric Chondroitin Sulfate Oligosaccharides Using a Chemical Derivatization Strategy. Huang R, Pomin VH, Sharp JS. J Am Soc Mass Spectrom 2011, 22:1577-87;
  14. Recent Demands of Glycomics: Subprojects and the Role of New Journals. Pomin, VH. J Glycobiol, OMICS Group 2011, 1:102e;
  15. Fucanome and Galactanome: Marine Glycomics Contribution. Pomin VH. J Glycobiol, OMICS Group 2011, 1:101;
  16. Current Glycomics´ Approaches: Subprojects and Journals. Pomin VH. J Glycom & Lipidom, OMICS Group 2011, 2:2;
  17. Exploiting enzyme specificities in digestion of chondroitin sulfates A and C: production of well-defined hexasaccharides. Pomin VH, Park Y, Huang R, Heiss C, Sharp JS, Azadi P, Prestegard JH. Glycobiology 2012, 22:826-38;
  18. Structure versus Anticoagulant and Antithrombotic Actions of Marine Sulfated Polysaccharides. Pomin VH, Mourão PA. Revis Bra Farmacogn 2012, 22:921-938;
  19. Residual keratan sulfate in chondroitin sulfate formulations for oral administration. Pomin VH, Piquet AA, Pereira MS, Mourão PA. Carbohydr Pol 2012, 90: 839-846;
  20. Fucanomics and galactanomics: Current status in drug discovery, mechanisms of action and role of the well-defined structures. Pomin VH. Biochem Biophys Acta-Gen Subj 2012, 1820:1971-1979;
  21. Fucanomics and galactanomics: Marine distribution, medicinal impact, conceptions, and challenges. Pomin VH. Mar Drugs 2012, 10: 793-811;
  22. Advances in glycosaminoglycanomics by 15N-NMR spectroscopy. Pomin VH. Anal Bioanal Chem 2012, 405:3035-3048;
  23. Marine sulfated glycans with serpin-unrelated anticoagulant properties. Glauser BF, Mourão PA, Pomin VH. Adv Clin Chem 2013, 62:269-303;
  24. Current status of fucanomics and galactanomics in drug discovery and glycomics. Pomin VH. J Glycobiol, OMICS Group 2013, 2:104;
  25. Testimonial for Journal of Glycobiology: a significant contribution of OMICS Publishing Group towards the progress of glycobiology and glycomics. Pomin VH. J Glycobiol, OMICS Group 2013, (http://www.omicspublishinggroup.org/journals/glycobiology/);
  26. NMR Chemical Shifts in Structural Biology of Glycosaminoglycans. Pomin VH. Anal Chem 2014, 86: 65-94;
  27. How to analyze the anticoagulant and antithrombotic mechanism of action in fucanome and galactanome? Pomin VH. Glycoconj J 2014, 31:89-99;
  28. Is the antithrombotic effect of sulfated galactans independent of serpin? Quinderé AL, Santos GR, Oliveira SN, Glauser BF, Fontes BP, Queiroz IN, Benevides NM, Pomin VH, Mourão PA. J Thromb Haemost 2014, 12:43-53;
  29. Marine medicinal glycomics. Pomin VH. Front Cell Infect Microbiol 2014, 4:5;
  30. Holothurian fucosylated chondroitin sulfate. Pomin VH. Mar Drugs 2014, 12:232-254.
  31. Solution NMR conformation of glycosaminoglycans. Pomin VH. Progr Biophys Mol Biol 2014, 114:61-68.
  32. Specific sulfation and glycosylation – a structural combination for the anticoagulation of marine carbohydrates. Pomin VH. & Mourão PA. Front Cell Infect Microbiol 2014, 4:33;
  33. Anticoagulant motifs of marine sulfated glycans. Pomin VH. Glycoconj J 2014, 31:341-344;
  34. NMR-based dynamics of free glycosaminoglycans in solution. Pomin VH. Analyst 2014, 139:3656-3665.
  35. Unique properties of human β-defensin 6 (hBD6) and glycosaminoglycan complex: sandwich-like dimerization and competition with the chemokine receptor 2 (CCR2) binding site. de Paula VS, Pomin VH, Valente AP. J Biol Chem 2014, 289: 22969-22979;
  36. Biological findings from the recent NMR-based studies of glycosaminoglycan-protein interactions. Pomin VH. Glycobiology 2014, 24:991-1003;
  37. Structural and functional analyses of bovine and porcine intestinal heparins confirm they are different drugs. Santos GR, Tovar AM, Capillé NV, Pereira MS, Pomin VH, Mourão PA. Drug Discov Today 2014, 19: 1801-1807;
  38. Sea, carbohydrates and clotting: a triad on the road of drug discovery. Pomin VH. Mini Rev Med Chem 2014, 14:717-724;
  39. Heparin-Binding Proteins (Chemokines and Defensins) and their complexes with glycosaminoglycans from the solution NMR perspective. Pomin VH. Curr Protein Pept Scien 2014, 15:738-744;
  40. Keratan sulfate: An up-to-date review. Pomin VH. Int J Biol Macromol 2014, 72C:282-289;
  41. Structural and functional analyses of biosimilar enoxaparins available in Brazil. Oliveira SN, Santos GR, Glauser BF, Capille NV, Queiroz IN, Pereira MS, Pomin VH, Mourão PA. Thromb Haemost 2015, 113:53-65;
  42. Impact of sulfation pattern on the conformation and dynamics of sulfated fucan oligosaccharides by NMR and MD. Queiroz IN, Wang X, Glushka J, Santos GR, Valente AP, Prestegard JH, Woods RJ, Mourão PA, Pomin VH. Glycobiology 2015, 25: 535-547;
  43. Sulfated glycans in inflammation. Pomin VH. Eur J Med Chem 2015, 92C: 353-369;
  44. Sulfated glycans in sea urchin fertilization. Pomin VH. Glycoconj J 2015, 32: 9-15;
  45. Current structural biology of the heparin interactome. Pomin VH, Mulloy B. Curr Opin Struct Biol 2015, 34: 17-25;
  46. NMR structural biology of invertebrate glycosaminoglycans of unique structure and potential use in medicine. Pomin VH. Carbohydr Res 2015, 413: 41-30;
  47. Antimicrobial sulfated glycans: structure and function. Pomin VH. Curr Top Med Chem 2015 (in press);
  48. A dilemma in the glycosaminoglycan-based therapy: synthetic or naturally unique molecules? Pomin VH. Med Res Rev 2015, 35: 1195-1219;
  49. Medical gains of chondroitin sulfate upon fucosylation. Pomin VH. Curr Med Chem 2015, 22: 4166-4176;
  50. Marine Non-Glycosaminoglycan Sulfated Glycans as Potential Pharmaceuticals. Pomin VH. Pharmaceuticals (Basel) 2015, 8: 848-864;
  51. NMR structural biology of sulfated glycans. Soares PAG, Queiroz, INL, Pomin VH. Biomol Struc & Dyn 2016 (in press);
  52. Dual and antagonic therapeutic effects of sulfated glycans. Pomin VH. Bioorg & Med Chem 2016, 24: 3965-3971;
  53. Phylogeny, structure, function, biosynthesis and evolution of sulfated galactose-containing glycans. Pomin VH. Int J Biol Macromol 2016, 84: 372-379;
  54. NMR-based conformation and dynamics of a tetrasaccharide-repeating sulfated fucan substituted by different counterions. Soares PAG; Queiroz INL; Santos GR; Mourão PA; Pomin VH. Biopolymers 2016, 105: 840-851;
  55. Paradigms in the structural biology of the mitogenic ternary complex FGF:FGFR:heparin. Pomin VH. Biochimie 2016, 127: 214-226;
  56. Oligosaccharides from the 3-linked 2-sulfated alpha-L-fucan and alpha-L-galactan show similar conformation but different dynamics. Queiroz INL, Vilela-Silva AC, Pomin VH. Glycobiology 2016, 26: 1257-1264;
  57. (1)H and (15)N NMR analyses on heparin, heparan sulfates and related monosaccharides confirm fast exchange property of the N-sulfo-glucosamine sulfamate proton. Pomin VH. Pharmaceuticals (Basel) 2016, 9: 58;
  58. The contribution of Glycobiology to the Zika outbreak in the Americas. Pomin VH. Glycobiology 2016, 26: 680-682;
  59. Sulfated glycans and related digestive enzymes in the Zika virus infectivity: potential mechanisms of virus-host interaction and perspectives in drug discovery. Pomin VH. Interdiscip Perspect Infect Dis 2017, 2017:1-8;
  60. The sea as a rich source of structurally unique and medically active glycosaminoglycans and mimetics. Vasconcelos, AA, Pomin VH. Microorganisms 2017, 5(3):pii: E51;
  61. Synthetic oligosaccharide libraries and microarray technology: a powerful combination for the success of the current glycosaminoglycan interactomics. Pomin VH, Wang X. ChemMedChem 2018, 13(7):648-661;
  62. Glycosaminoglycans and Proteoglycans. Pomin VH, Mulloy B. Pharmaceuticals (Basel) 2018, 1(1). pii: E27.
  63. Marine Carbohydrate-Based Compounds with Medicinal Properties. Vasconcelos AA, Pomin VH. Mar Drugs 2018, 16(7). pii: E233.
  64. Anticoagulant and Antithrombotic Properties of Three Structurally Correlated Sea Urchin Sulfated Glycans and Their Low-Molecular-Weight Derivatives. Vasconcelos AA, Sucupira ID, Guedes AL, Queiroz IN, Frattani FS, Fonseca RJ, Pomin VH. Mar Drugs 2018, 16(9). pii: E304.
  65. Glycosaminoglycan-Protein Interactions by Nuclear Magnetic Resonance (NMR) Spectroscopy. Pomin VH, Wang X. Molecules 2018 Sep 11;23(9). pii: E2314.
  66. Chondroitin sulfate isolated from the secretion of the venom-producing parotoid gland of Brazilian bufonid. da Silva HAM, de Queiroz INL, Francisco JS, Pomin VH, Pavão MSG, de Brito-Gitirana L. Int J Biol Macromol 2018, 124:548-556.
  67. New antithrombotic carbohydrates from the sea. Pomin VH. Mar Drugs 2019 (in writing);
  68. Current and potential therapeutic application of galactosaminoglycans. Vasconcelos AA, Gonzales A, Vignovich W, Mulloy B, Pomin VH. Eur J Med Chem 2019, (invited paper);
  69. Solution 3D structures of fucose and the tetrasaccharide repeating building block of the sulfated fucan from Lytechinus variegatus as seen by NMR and MD. Bezerra FF, Aderibigbe A, Liu H, Sharp J, Doerksen R, Pomin VH. J Struc Biol 2019 (in writing).

Book chapter and book editor

  1. Chapter 7 – Analysis of Cellulose Using NMR Spectroscopy. Author: Vitor H. Pomin. Book: Cellulose: Structure and Properties, Derivatives and Industrial Uses, at Nova Science Publishers. Editors: Arnaud Lejeune and Thibaut Deprez, 2010.
  2. Chapter 11 – Structure and Use of Algal Sulfated Fucans and Galactans. Author: Vitor H. Pomin. Book: Handbook of Marine Macroalgae, at Wiley-Blackwell. Editor: Se-Kwon Kim, 2011.
  3. Book: Seaweed: Ecology, Nutrient Composition, and Medicinal Uses, at Nova Science Publishers. Editor: Vitor H. Pomin, 2011.
  4. Chapter 1 – The Science of Repeating Disaccharide-Composed Glycosaminoglycans. Author: Vitor H. Pomin and Younghee Park. Book: Advances in Chemistry Research, vol. 12, at Nova Science Publishers. Editor: James C. Taylor, 2011.
  5. Chapter 12 – Structure-Function Relationship of Anticoagulant and Antithrombotic Well-Defined Sulfated Polysaccharides from Marine Invertebrates. Author: Vitor H. Pomin. Book: Marine Medicinal Foods. Volume 65, Implications and Applications: Animals and Microbes (Advances in Food and Nutrition Research), at Academic Press. Editor: Se-Kwon Kim, 2012.
  6. Chapter 19 – Marine Sulfated Polysaccharides with Unusual Anticoagulant Action through an Additional Unrelated-Natural Inhibitors Mechanism. Author: Bianca Glauser, Paulo AS Mourão, Vitor H. Pomin. Book: Marine Nutraceuticals: Prospects & Perspectives, at Taylor & Francis Group. Editor: Se-Kwon Kim, 2012.
  7. Chapter 4 – Unraveling Glycobiology by NMR Spectroscopy. Author: Vitor H. Pomin. Book: Glycosylation, at InTech. Editor: Stefana Petrescu, 2012.
  8. Book: Marine Medicinal Glycomics, at Nova Science Publishers. Editor: Vitor H. Pomin, 2013.
  9. Chapter 8 – Structure-​Function Relationship of Anticoagulant and Antithrombotic Marine Sulfated Polysaccharides of Well-Defined Chemical Structures. Author: Vitor H. Pomin. Book: Marine Medicinal Glycomics, at Nova Science Publishers, editor: Vitor H. Pomin, 2013.
  10. Chapter 9 – Marine sulfated glycans with an unusual serpin-independent anticoagulant action. Authors: Bianca F Glauser, Paulo A Mourão, and Vitor H. Pomin. Book: Marine Medicinal Glycomics; at Nova Science Publishers. Editor: Vitor H. Pomin, 2013.
  11. Book: Chondroitin sulfate: structure, uses and health implications; at Nova Science Publishers. Editor: Vitor H. Pomin, 2013.
  12. Chapter 4 – Understanding specificities in enzymatic digestions of chondroitin sulfates A and C by monitoring sulfation patterns of the produced oligosaccharides. Author: Vitor H. Pomin. Book: Chondroitin sulfate: structure, uses and health implications; at Nova Science Publishers. Editor: Vitor H. Pomin, 2013.
  13. Chapter 8 – Fucosylated chondroitin sulfate: a serpin-independent anticoagulant polysaccharide. Author: Vitor H. Pomin. Book: Chondroitin sulfate: structure, uses and health implications; at Nova Science Publishers. Editor: Vitor H. Pomin, 2013.
  14. Chapter 11 – Structural analysis of chondroitin sulfates and their derivatives by 15N-NMR spectroscopy. Authors: Vitor H. Pomin. Book: Chondroitin sulfate: structure, uses and health implications; at Nova Science Publishers. Editor: Vitor H. Pomin, 2013.
  15. Book: Seaweed: Agricultur​al Uses, Biological and Antioxidant Agents; at Nova Science Publishers. Editor: Vitor H. Pomin, 2014.
  16. Book: Galactose: Chemical Structure, Dietary Sources and Clinical Significance; at Nova Science Publishers., Editor: Vitor H. Pomin, 2014.
  17. Book: Hyaluronan: Medical Uses, Biological Synthesis and Role in Wound Healing; at Nova Science Publishers. Editor: Vitor H. Pomin, 2014.
  18. Chapter: Sulfated polysaccharide-dependent activation of sperm in sea urchin fertilization. Authors: Ana Cristina Vilela-Silva, Vitor H. Pomin, Paulo A.S. Mourão. Book: Glycoscience: Biology and Medicine. Section: Develpmental Glycobiology; at Springer. Editors: T. Endo, P.H. Seeberger, G.W. Hart, C.-H. Wong, N. Taniguchi, 2014.
  19. Chapter 10: Aanlysis of glycosaminoglycans by 15N-NMR spectroscopy. Authors: Vitor H. Pomin. Book: NMR in Glycoscience and Glycotechnology; at Royal Society of Chemistry. Editors: Thomas H. Peters and Koichi Kato, 2017.
  20. Chapter 6 – Structural mechanisms involved in mild- acid hydrolysis of a defined tetrasaccharide-repeating sulfate fucan. Authors: Francisco F. Bezerra, Vitor H. Pomin. Book: Enzymatic Technologies for Marine Polysaccharides; at CRC Press Taylor & Francis Publisher. Editor: Antonio Trincone, 2019.
  21. Chapter 29 – Leveraging genome sequencing strategies for basic and applied algal research, exemplified by case studies. Authors: Ariana A. Vasconcelos, Vitor H. Pomin. Book: Handbook of Algal Technologies and Phytochemicals: Nutritional, Nutraceutical, Pharmaceutical and Multifarious Applications; at CRC Press USA. Editors: Prof. Dr. Ravishankar Gokare and Dr. Rangarao Ambati, 2019.