Hands-on Course in Tablet Technology

The University of Mississippi


LAB 1 – Preformulation

Evaluate properties of a pharmaceutical API, powders and polymers utilizing:

  • Particle surface area analysis
  • Porosity analysis
  • Particle size and shape analysis
  • Density analysis
  • Moisture adsorption/desorption isotherms
  • Texture analysis
  • Thermogravimetric analysis
  • Differential scanning calorimetry


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LAB 2 – Granulation and Extrusion/Spheronization

Processing of a pharmaceutical API and excipients to form granules and extrudates by:

  • High shear mixing and wet granulation
  • Low shear mixing and wet granulation
  • Extrusion/Spheronization
  • Fluid bed drying
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LAB 3 – Tableting

Evaluate excipient/drug compressibility and compressibility of wet granulated vs. direct compression tablet formulations utilizing:

  • Instrumented single punch tablet press
  • Instrumented rotary tablet press
  • Equipment to monitor weight, thickness and breaking strength of tablet compacts
  • Software to determine scalability from small to large scale production presses
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LAB 4 – Hot Melt Extrusion, 3D Printing and Tablet Evaluation

Evaluate processing of hot melt extruded forms using:

  • Hot melt extruder
  • 3D Printing

Perform tests to evaluate quality control attributes of tablets using:

  • Tablet dissolution apparatus, real time and interval drug release testing
  • Tablet disintegration testing
  • Tablet friability testing
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LAB 5 – Fluid Bed Granulation/Particle Coating and Tablet Pan Coating

Evaluate granulation of an API/excipient blend and film coating of non-pareil particles using:

  • Fluid bed granulator/Wurster particle coater

Pan coat tablets using:

  • Side vented tablet coating pan
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Upcoming Courses

  • May 19 – 24, 2024     Hands-on Course in Tablet Technology (Oxford, MS)