The role of glycosylation in cell-state transitions during development and disease
Project Description:
Cell-state transitions involve the coordinated transformation of cellular identity, physiology, and morphology. These cellular processes occur at pivotal points in cardiac development and in the pathogenesis of cardiac disease. We are investigating the role of glycans in regulating cell state transitions. In particular, we are investigating 1) the role of glycans attached to oncofetal isoform of fibronectin, 2) glycocalyx dynamics during cardiac cell state transitions, and 3) the role of the O-glcNAC in fetal hyperglycemia-related cardiac cell state transitions. Our goal is to elucidate fundamental principles underlying the biology of glycans in cardiac cell state transitions in order to better understand cardiac development, congenital heart defects and cardiac disease.
Contact Information:
Dr. Joshua Bloomekatz Assistant Professor, Department of Biology Shoemaker Hall 297 662-915-3072 josh@olemiss.edu https://thebloomekatzlaboratory.org